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MitochondrialResearch

MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA Type-c

A mitochondrial-derived peptide dubbed an 'exercise mimetic' that reverses age-related insulin resistance and enhances fat oxidation even in sedentary individuals.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · 12+ years in peptide therapeutics

Half-Life

~4–6 hours

Typical Dose

5–10 mg weekly

Administration

Subcutaneous injection

Mechanism of Action

Activates AMPK signaling and folate/methionine metabolism to shift cellular energy from glucose dependency to fat oxidation, improving metabolic homeostasis.

Key Research Areas

mitochondrialexercise mimeticmetabolisminsulin sensitivity

Frequently Asked Questions

What is MOTS-c?▾
A mitochondrial-derived peptide dubbed an 'exercise mimetic' that reverses age-related insulin resistance and enhances fat oxidation even in sedentary individuals.
How does MOTS-c work?▾
Activates AMPK signaling and folate/methionine metabolism to shift cellular energy from glucose dependency to fat oxidation, improving metabolic homeostasis.
What is the recommended dosage for MOTS-c?▾
The typical research dosage is 5–10 mg weekly, administered via Subcutaneous injection. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of MOTS-c?▾
The half-life of MOTS-c is approximately ~4–6 hours. This affects dosing frequency and timing in research protocols.
Is MOTS-c FDA approved?▾
MOTS-c is currently classified as "Research" and is not FDA approved for general use. It is available for research purposes or through compounding pharmacies depending on your jurisdiction.

Research Disclaimer

The information provided about MOTS-c is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.

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