PeptidePicker
Get Started
Home/Peptides/Retatrutide
Weight LossClinical Trials

Retatrutide

Also known as: LY3437943 · Triple G agonist

The most powerful weight loss peptide in clinical development, targeting three metabolic receptors simultaneously. Achieved 24.2% body weight reduction in Phase 2 trials.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · 12+ years in peptide therapeutics

Half-Life

~6 days

Typical Dose

8–12 mg weekly

Administration

Subcutaneous injection

Mechanism of Action

Triple agonist of GLP-1, GIP, and glucagon receptors, combining appetite suppression with increased energy expenditure and enhanced liver fat metabolism.

Key Research Areas

weight losstriple agonistGLP-1GIPglucagon

Frequently Asked Questions

What is Retatrutide?▾
The most powerful weight loss peptide in clinical development, targeting three metabolic receptors simultaneously. Achieved 24.2% body weight reduction in Phase 2 trials.
How does Retatrutide work?▾
Triple agonist of GLP-1, GIP, and glucagon receptors, combining appetite suppression with increased energy expenditure and enhanced liver fat metabolism.
What is the recommended dosage for Retatrutide?▾
The typical research dosage is 8–12 mg weekly, administered via Subcutaneous injection. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of Retatrutide?▾
The half-life of Retatrutide is approximately ~6 days. This affects dosing frequency and timing in research protocols.
Is Retatrutide FDA approved?▾
Retatrutide is currently classified as "Clinical Trials" and is not FDA approved for general use. It is available for research purposes or through compounding pharmacies depending on your jurisdiction.

Research Disclaimer

The information provided about Retatrutide is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.

Related Peptides in Weight Loss

Semaglutide

Ozempic · Wegovy

Tirzepatide

Mounjaro · Zepbound

Liraglutide

Victoza · Saxenda

Dulaglutide

Trulicity · LY2189265

Back to All PeptidesFind Your Peptide — Take the Quiz