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ClinicalFDA Approved

Pentosan Polysulfate

Also known as: Elmiron · PPS · SP-54

The only FDA-approved oral treatment for interstitial cystitis (IC), acting as a biological mucosal sealant for the bladder wall.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · 12+ years in peptide therapeutics

Half-Life

~4.8 hours

Typical Dose

100 mg three times daily

Administration

Oral

Mechanism of Action

Binds to glycosaminoglycan receptors on damaged urothelium, restoring the protective bladder lining and reducing inflammatory pain.

Key Research Areas

clinicalFDA approvedbladderinterstitial cystitis

Frequently Asked Questions

What is Pentosan Polysulfate?▾
The only FDA-approved oral treatment for interstitial cystitis (IC), acting as a biological mucosal sealant for the bladder wall.
How does Pentosan Polysulfate work?▾
Binds to glycosaminoglycan receptors on damaged urothelium, restoring the protective bladder lining and reducing inflammatory pain.
What is the recommended dosage for Pentosan Polysulfate?▾
The typical research dosage is 100 mg three times daily, administered via Oral. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of Pentosan Polysulfate?▾
The half-life of Pentosan Polysulfate is approximately ~4.8 hours. This affects dosing frequency and timing in research protocols.
Is Pentosan Polysulfate FDA approved?▾
Yes, Pentosan Polysulfate is FDA approved for specific medical indications. Consult your physician for proper medical guidance.

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Research Disclaimer

The information provided about Pentosan Polysulfate is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.

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