ClinicalFDA Approved
Pentosan Polysulfate
Also known as: Elmiron · PPS · SP-54
The only FDA-approved oral treatment for interstitial cystitis (IC), acting as a biological mucosal sealant for the bladder wall.
Reviewed by Dr. Sarah Mitchell, PharmD, BCPS
Lead Researcher · 12+ years in peptide therapeutics
Half-Life
~4.8 hours
Typical Dose
100 mg three times daily
Administration
Oral
Mechanism of Action
Binds to glycosaminoglycan receptors on damaged urothelium, restoring the protective bladder lining and reducing inflammatory pain.
Key Research Areas
clinicalFDA approvedbladderinterstitial cystitis
Frequently Asked Questions
What is Pentosan Polysulfate?▾
The only FDA-approved oral treatment for interstitial cystitis (IC), acting as a biological mucosal sealant for the bladder wall.
How does Pentosan Polysulfate work?▾
Binds to glycosaminoglycan receptors on damaged urothelium, restoring the protective bladder lining and reducing inflammatory pain.
What is the recommended dosage for Pentosan Polysulfate?▾
The typical research dosage is 100 mg three times daily, administered via Oral. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of Pentosan Polysulfate?▾
The half-life of Pentosan Polysulfate is approximately ~4.8 hours. This affects dosing frequency and timing in research protocols.
Is Pentosan Polysulfate FDA approved?▾
Yes, Pentosan Polysulfate is FDA approved for specific medical indications. Consult your physician for proper medical guidance.
Research Disclaimer
The information provided about Pentosan Polysulfate is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.