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CognitiveResearch

PE-22-28

Also known as: PE22-28 · Spadin analog

A spadin analog studied for rapid antidepressant-like effects, working through TREK-1 potassium channel modulation.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · 12+ years in peptide therapeutics

Half-Life

~2–4 hours

Typical Dose

100–500 mcg

Administration

Subcutaneous injection or intranasal

Mechanism of Action

Blocks TREK-1 potassium channels to enhance serotonergic and noradrenergic neurotransmission, producing fast-acting mood elevation.

Key Research Areas

antidepressantcognitiveTREK-1mood

Frequently Asked Questions

What is PE-22-28?▾
A spadin analog studied for rapid antidepressant-like effects, working through TREK-1 potassium channel modulation.
How does PE-22-28 work?▾
Blocks TREK-1 potassium channels to enhance serotonergic and noradrenergic neurotransmission, producing fast-acting mood elevation.
What is the recommended dosage for PE-22-28?▾
The typical research dosage is 100–500 mcg, administered via Subcutaneous injection or intranasal. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of PE-22-28?▾
The half-life of PE-22-28 is approximately ~2–4 hours. This affects dosing frequency and timing in research protocols.
Is PE-22-28 FDA approved?▾
PE-22-28 is currently classified as "Research" and is not FDA approved for general use. It is available for research purposes or through compounding pharmacies depending on your jurisdiction.

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Research Disclaimer

The information provided about PE-22-28 is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.

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